Open Science

Open-source PET scatter correction

We believe scatter estimation, like other core reconstruction building blocks, should be freely available and reproducible rather than locked away in vendor-specific black boxes. That's why openSSS, our open-source implementation of the TOF-aware single-scatter-simulation algorithm for 3D PET, is published openly on GitHub for anyone to use, inspect, and build on.

Diagram of single-scatter simulation geometry: a source S sends a photon pair toward detectors A and B, one of which scatters (solid line) away from the true line of response (dashed line)
Single-scatter simulation (SSS) geometry: for source S, the scattered path (solid) is estimated relative to the true line of response between A and B (dashed). Adapted from the original publication below.

openSSS was co-developed with the developers of CASToR (Customizable and Advanced Software for Tomographic Reconstruction), the open-source toolkit for PET/SPECT/CT reconstruction, so that scatter correction integrates directly into an existing open reconstruction pipeline instead of requiring a separate, closed one.

View openSSS on GitHub →

openSSS: an open-source implementation of scatter estimation for 3D TOF-PET

Rodrigo José Santo, André Salomon, Hugo W.A.M. de Jong, Simon Stute, Thibaut Merlin, Casper Beijst
EJNMMI Physics 12 (1), 17 · 2025
Contributors

Collaborators

openSSS was originally developed by:

R. José Santo1, A. Salomon2, H. W.A.M. de Jong3, S. Stute4, 5, T. Merlin6, C. Beijst1

  1. UMC Utrecht, Imaging & Oncology, Utrecht, The Netherlands
  2. Philips Research Europe, Eindhoven, The Netherlands
  3. UMC Utrecht, Radiology & Nuclear Medicine, Utrecht, The Netherlands
  4. CHU de Nantes, Nuclear Medicine, Nantes, France
  5. Université d'Angers, Université de Nantes, CRCINA, Inserm, CNRS, Pays de la Loire, France
  6. University of Brest, LaTIM, INSERM, UMR 1101, Brest, France

The Python version was developed with additional contributions by:

T. Klinsuwan1, A. Hopkins1, H. R. Kanan1, M. Colarieti-Tosti1, and J. Neele2

  1. KTH Royal Institute of Technology, Biomedical Engineering and Health Systems, Stockholm, Sweden
  2. UMC Utrecht, Imaging & Oncology, Utrecht, The Netherlands